Continuum Computational Modeling of Biophysical Systems

Continuum Computational Modeling of Biophysical Systems

This seminar will explore how continuum modeling and high-performance computing can be combined to study biophysical systems from the nano to the millimeter scale. Starting at the atomic scale, we will see how Poisson-Boltzmann calculations can help us understand the fundamental biophysical mechanisms of deforming proteins, focusing specifically on the opening of the covid-19 spike protein and its role in the infection pathway. Zooming out, we will then focus on cellular material transfer during cell division, a crucial process that could shed light on the development of prion diseases, such as mad cow and Creutzfeldt-Jakob. Finally, we will learn how statistical physical and traditional computational fluid dynamics can help us shine the light on the mesmerizing properties of bacterial colonies and other active fluids. This seminar is intended for a broad computational audience and does not require any prior biophysical background.

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